Endocrine Abstracts

High protein diets are highly satiating but hard to maintain. By understanding the mechanisms underlying these effects we may be able to identify new anti-obesity therapies. Protein is broken-down into amino acids in the gut which are detected by a series of nutrient sensors. The calcium sensing receptor (CaSR) is primarily activated by calcium ions, but is positively allosterically modulated by aromatic amino acids, especially L-phenylalanine. Sti...

High protein diets are highly satiating but hard to maintain. By understanding the mechanisms underlying these effects we may be able to identify new anti-obesity therapies. Protein is broken-down into amino acids in the gut which are detected by a series of nutrient sensors. The calcium sensing receptor (CaSR) is primarily activated by calcium ions, but is positively allosterically modulated by aromatic amino acids, especially L-phenylalanine. Sti...

In late pregnancy the mother must mobilise considerable energy stores to support fetal growth. Failure to appropriately nourish the fetus has significant obstetric consequences – gestational diabetes and fetal growth restriction (FGR). Despite this, relatively little is known about how metabolic responses are stimulated in the mother, and how they may go wrong. We previously found that high levels of the product of an imprinted gene, Delta-like homologue-1 (D...